Tuesday, February 8, 2011

Chapter 11 - Regulation at the RNA level

Following with mechanisms of gene regulation at the RNA level, we discussed how translation can be repressed or activated by regulatory proteins and how can it be regulated via anti-sense RNA or alterations to ribosomes (we used phosphorilation of proteins in the ribosomal small subunit as an example).

We also discussed the role of RNA interference (RNAi) as a defense mechanism of eukaryotic cells against some viral infections, as a cell's mechanism for gene silencing, and as a research tool to study gene function by knocking-out genes.

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